Which two tuberculosis (TB) medications are known to interact negatively with other drugs?

Rifampin and ritonavir are known for their significant drug interactions. Rifampin is a potent inducer of the cytochrome P450 enzyme system, which plays a crucial role in the metabolism of many medications. This means that when rifampin is co-administered with other drugs, it can accelerate their breakdown, leading to decreased efficacy of those drugs. This is particularly important in the context of HIV treatments, as ritonavir, primarily used as a protease inhibitor, can also be affected by rifampin's action, necessitating careful monitoring and dose adjustments.

This understanding of drug interactions is vital for healthcare providers to ensure optimal treatment outcomes and to avoid complications arising from decreased therapeutic levels of co-administered medications. Therefore, the interaction between rifampin and ritonavir highlights the importance of considering potential drug interactions when treating patients for tuberculosis, especially in those who may also require therapy for other conditions.